A Long Island research and development firm that counts big names like Johnson & Johnson and Siemens among its clients has moved into a new $5 million headquarters.

MIDI, short for Montalbano Innovation & Development Inc., will share the 15,000-square-foot building — located at 226 E. Main St. in the Village of The Branch in Smithtown — with a diagnostic imaging center for Northwell Health, formerly North Shore-LIJ Health System. MIDI is taking about 6,500 square feet in the one-story building. The project was built by Stalco Construction of Islandia.

The company provides market research and product engineering and design services for the biotech and medical industries, and boasts companies such as GE Healthcare, Siemens, and Johnson & Johnson among its clientele.

MIDI specializes in meeting FDA regulatory standards for medical devices, said brothers Gregory and Christopher Montalbano, principals and owners of MIDI.

They said the open office design of the new headquarters will benefit collaboration among the firm’s 30 engineers, designers and market researchers, and offers a geographic advantage over their previous Great Neck and Ronkonkoma locations.

The site puts the company in proximity to Stony Brook University Hospital and the school’s Center for Biotechnology. In addition, it provides MIDI easier access to Boston, where the company finds many of its larger medical industry clients.

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“The location is key as far as having access to the Boston area through the ferry,” said Christopher Montalbano. “Those things are important.”

The company, founded in 1972 by their father, Anthony Montalbano, says it has generated more than 500 patents for clients over the past 40 years, developing products such as CT scanners, anesthesiology equipment, spinal implants and Internet-connected electrocardiogram machines for companies.

Anthony Montalbano did “cosmetic design” work for some of Fonar Corp.’s earliest MRI scanners, including the world’s first mobile MRI, said Daniel Culver, director of communications for Fonar.

Since then, MIDI has continued to grow and is typically working on six to seven products at a time, all in different stages of development, Christopher Montalbano said. MIDI develops about six products a year for client companies.

“What I really enjoy about this industry is that we get to work with so many groups on so many different programs that you never get bored,” Gregory Montalbano said.