The estate known as Home Plate Farm in Sudbury, Mass., is on the market for $1.65 million.
Ruth, who for decades held the major league career home-run record with 714, lived in the home from 1922 to 1926, according to broker Scott Adamson, of Coldwell Banker Residential brokerage.
"This is a great old antique house," Adamson said Monday, estimating the home dates to about 1800. "It's got a ton of modern features, but I think Babe Ruth would still recognize it even today because it retains many of the original features."
Ruth played for the Red Sox from 1914 to 1919, then for the Yankees from 1920 to 1934. His playing salary over a 22-year career was less than $911,000, according to baseball-reference.com.
The 5,000-square-foot, five-bedroom, 31/2-bathroom home on a two-acre plot has undergone extensive renovations since the 1920s, including "a chef's dream kitchen, richly detailed family room, a sunny master suite with vaulted ceilings" and more, the listing says.
But some of Ruth's personal touches remain. One room even has burn marks on the floor where Ruth is said to have flicked his cigar ashes, Adamson said.
The property also includes a 5,000-square-foot barn with stables, office space, garage bays and a one-bedroom apartment with a full kitchen and bathroom.
"This is truly a one-of-kind opportunity to own a piece of history," Adamson said.
The current owners have lived in the home about 20 miles west of Boston nearly 30 years and are "moving on," Adamson said.
The only drawback may be the occasional baseball fan who stops by to take a look, said Aglaia Pikounis, a spokeswoman for Coldwell Banker's parent company.
The home is also not far from Willis Pond, where the remains of a piano that reportedly once belonged to Ruth is thought to be submerged. Legend has it that Ruth, who rented a hunting cabin on the pond, pushed an upright piano onto the ice one winter during a party, then left it there until the ice melted and piano plunged into the water.