In a Super Bowl that is about to be quite literally stuffed with ads featuring major celebrities, here’s one that already stands out: Dame Helen Mirren in a commercial for Budweiser beer in which she rebukes drunken drivers as an “oxygen-wasting form of pollution.”

Released Tuesday, the ad featuring Mirren — who recently starred as Hedda Hopper in the big screen biopic of blacklisted screenwriter Dalton Trumbo — is seated at a table in a darkened restaurant, with a bottle of Bud and rather large, overstuffed hamburger in front of her.

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Then, after referring to herself as “a notoriously frank and uncensored British lady” — a well-established fact, by the way — she gets around to what’s really on her mind.

She decries drunken drivers as an “utterly useless, oxygen-wasting form of pollution . . . a selfish coward. If your brain was donated to science, science would return it.

“So stop it. Chances are, you’re a fun, solid human being — don’t be a pillock.”

A “pillock”? Not flattering — a moron.

Meanwhile, in another major Super Bowl pre-release Tuesday, Drake is featured in a commercial for T-Mobile — a parody of his megahit, “Hotline Bling” (which racked up more than 435 million YouTube views since its October release). In this one, he endures a series of mindless suggestions about how to improve the song, with the tag: “Other wireless carriers ruin everything.”