George Clooney "ER" (1994-99)

Pre-Op: The 46-year-old nephew of singer Rosemary Clooney had been kicking around Hollywood nearly a decade doing TV series after TV series, including a stint as a character named Ace on a 1984-85 CBS sitcom ironically called "E/R," and some bad low-budget films before he put on the stethoscope as Dr. Douglas Ross on the long-running NBC medical series.

Scrubs: Women always love "bad boys" and they didn't get much badder - at least for the first few seasons - than Clooney's charming, womanizing pediatrician. In one episode, a one-night stand died while with him. He didn't even know her name. Ross, though, tried to redeem himself on numerous occasions, eventually being put on probation when he tried to help a dying young boy end his life.

Hollywood quickly came knocking. Clooney made several films while on the series, including "From Dusk Till Dawn," "The Peacemaker," the dreadful "Batman & Robin" and "Out of Sight," his first film with a frequent collaborator, director Steven Soderbergh.

Post-Op: One of Hollywood's major players - and noted humanitarians - Clooney picked up the Oscar two years ago for supporting actor in "Syriana." The same year, he also received nominations for directing and co-writing his historical drama "Good Night, and Good Luck." He received his first Academy Award nomination in the lead actor category for 2007's thriller "Michael Clayton." Clooney's most recent movie as star and director was the screwball football comedy "Leatherheads," which hasn't exactly scored a touchdown at the box office. (NBC Universal)