Four men were arrested Friday after police found weapons and large quantities of drugs in a Medford home linked to fatal drug overdoses, authorities said.

Officers from the Suffolk County Police Department, New York State Police and the East End Drug Task Force executed a search warrant shortly before 2 p.m. Friday at the home on Norfleet Lane, where they found 1.5 kilograms of fentanyl, 550 grams of crack cocaine, heroin, Xanax and other drugs, as well as three weapons and $10,000 cash, according to Suffolk police Commissioner Timothy Sini.

Though the suspects had fled, police later arrested them, Sini said. Three now face drug charges.

Brandyn Liggon, 26, was charged with criminal possession and sale of a controlled substance and criminal possession of weapons. Carl Washington, 39, was charged with criminal possession of a controlled substance and of marijuana. Both lived at the Norfleet Lane home, Sini said at a news conference Saturday.

Rondell Blue, 25, whose last known address was in Medford, was charged with criminal sale of a controlled substance. A fourth man was charged with loitering, Sini said.

The arrests followed a recent spike in opioid overdoses on Long Island and reflected the protracted surge in abuse of drugs like heroin and fentanyl nationwide.

“We are in the midst of an opioid epidemic,” Sini said, one that “touches all of our communities.”

The police commissioner stressed the ascendant danger of fentanyl, in particular — a synthetic opioid many times stronger than heroin.

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“Fentanyl is becoming public enemy number one,” he said.

The men arrested on the drug charges sold the illegal substances directly out of the Norfleet Lane home, which police connected to at least five drug overdoses, two of them fatal, Sini said.

Police could not say Saturday when the overdoses occurred.

Though Sini said he did not know if those arrested were affiliated with a gang, police think “they were a major retail supplier” of drugs. The street value of the fentanyl seized alone was more than $300,000 — equating to around 46,000 doses, he said.

“We are not going to stand for the peddling of this poison in our communities,” he said.

Liggon’s attorney, Andrew Heffernan of the Jon Manley law firm in Hauppauge, said in an emailed statement that “Mr. Liggon denies these allegations and looks forward to clearing his name.”

Jonathan Manley, Blue’s attorney, wrote in an email that “Mr. Blue does not reside at the residence and unequivocally denies selling or possessing any narcotics.”

Christopher M. Gioe, Washington’s attorney, wrote in an email that Washington has pleaded not guilty and that Suffolk prosecutors and police “have failed to provide us with any evidence to support their allegations.”