A search of a Deer Park home turned up “enough fentanyl to kill a dozen people,” Suffolk police Commissioner Timothy Sini said Saturday, referring to one of the drugs found in the house.

Three men — including one authorities said was linked to a fatal overdose in July — were arrested on drug charges Friday after Suffolk police executed a search warrant at the home.

Suffolk County police also seized 406 grams of crack cocaine, 204 grams of fentanyl, 65 grams of heroin, 429 Xanax tablets, a loaded handgun, ammunition, cash and drug gear while executing the search warrant at 61 Lincoln Ave. in Deer Park, Sini said Saturday.

“The message to drug dealers is that if you are selling drugs in Suffolk County, we are coming for you,” Sini said.

One of the men arrested Friday, Tashaun Wallace, 27, was linked to a fatal overdose that occurred July 9 in Bay Shore, Sini said. He declined to identify the victim.

“Fentanyl will likely be the leading cause of overdose deaths in 2017 just as it was in 2016. It’s important to target drug dealers who cause overdoses,” Sini said. Fentanyl is 50 to 100 times more potent than morphine.

Wallace and Kamaljot Kaur, 25, another man arrested at the Deer Park home, were charged with criminal possession of a controlled substance in the first degree, criminal possession of a controlled substance in the second degree and two counts of criminal possession of a controlled substance in the third degree.

A third man, Kevin Smith, 50, was charged with criminal possession of a controlled substance in the seventh degree.

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Sini said he expected additional charges related to the handgun also would be filed. “Right now that remains under investigation,” he said.

Sini said law enforcement alone couldn’t solve the opioid epidemic plaguing Long Island, and that it was important to provide treatment and support for addicts. But Friday’s arrests, he added, were significant because they removed a large amount of illicit drugs from the street.

“We need to prevent young people from getting hooked on this stuff,” Sini said.