Ricardo Medina-Baez, 41, of 248 E. Broadway, is charged with driving while intoxicated, police said, and was taken to an area hospital, where he was admitted with a head injury.
Police did not have details on his condition.
A female resident who was home at the time was not injured, police said.
At least three fire departments responded to the scene after the car burst into flames and then the house caught fire, police said.
Medina-Baez will be arraigned as soon as "medically practical," police said.