The two suspects wore masks and gloves when they entered the dollar store at 984 Hempstead Tpke. at about 6:50 p.m., detectives said.
One of the men showed a handgun while the other took an unspecified amount of cash and a cellphone. Both men were last seen driving eastbound on Hempstead Turnpike in a red Chevrolet Avalanche, police said.
Three employees were in the store at the time of the robbery. No injuries were reported.
Anyone with information can call Crime Stoppers at 800-244-8477. All calls will be kept confidential.