The one-car crash occurred at about 1:20 a.m., police said. Police said the road was reopened at about 8:15 a.m.
The driver, who police said was seriously injured, was taken to a hospital for treatment. Additional details were not immediately known.
The cause of the crash also was not known.
The crash closed the service road between exits 34 and 33, the New York State Department of Transportation said.