A fire inside a Bay Shore residence early Sunday led to the deaths of at least 4 kittens and left the home with “severe damage,” officials said.

No one was home at the time of the blaze, which broke out just after 1 a.m., said Bay Shore Fire Chief Ed Kunz.

Fire departments from Bay Shore, West Islip, Islip and Brentwood responded to the blaze, Kunz said.

Calls went out for assistance from the three other fire departments because responders from Bay Shore feared there were people inside the home, Kunz said.

Firefighters responded at about 1:15 a.m. to the house fire on Perkal Street, which Kunz said had consumed the entire front of the single-story home.

“We initially got the call as ‘occupants within,’ ” Kunz said. “[Callers] saw two cars in the driveway and said when there’s two cars in the driveway, there’s normally three people in the house.”

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Kunz didn’t have any information about the whereabouts of the home’s residents.

Responders rescued at least three kittens from the burning home, he said.

The fire was under control about 45 minutes to an hour after firefighters arrived, and responders remained at the scene until about 3 a.m., Kunz said. A Dodge Charger parked in the driveway also caught fire, he said.

Suffolk County police’s arson unit and the Islip Town fire marshals are investigating the fire’s cause and will have a report in about a week, he said.