A repaving project closes portions of Route 110 in Huntington Station starting Thursday, the state Department of Transportation said.

The off-peak daytime and nighttime closures are needed to repave a deteriorated section of the roadway between Henry Street and Lowndes Avenue, the agency said in a news release.

Between 10 a.m. and 3 p.m. Monday through Friday, Route 110 travel lanes will be shifted or closed, the agency said.

Work starts Thursday, with at least one northbound and one southbound travel lane staying open during midday construction hours.

Intermittent brief closures of all lanes may occur so crews can position heavy construction equipment.

advertisement | advertise on newsday

During overnight hours — from 10 p.m. to 6 a.m. — multiple lane closures will be needed. At times, alternating directional traffic could be in effect for a short distance; meaning traffic in one direction, northbound or southbound, will be stopped and traffic in the other direction will proceed, the agency said.

The work is part of the agency’s $11.6 million project to repair Long Island’s heavily traveled roadways.

Motorists are urged to use alternate routes whenever possible, and those who must travel in the Route 110 work zone are reminded to drive carefully for their safety as well as that of work crews, the agency said.

advertisement | advertise on newsday

Real-time travel information is available by calling 511 or visiting 511NY.org, the state’s official traffic and travel information source. Also, information is at informny.com.

Mobile users also can get DOT information on Twitter at @NYSDOTLI or at Facebook.com/NYSDOT.