The star-studded Ovarian Cancer Research Fund Alliance’s 19th annual Super Saturday NY returns to Water Mill on Saturday with discounted merchandise from nearly 150 luxury fashion brands and a few new shopping experiences.

The “Rolls-Royce of garage sales” will include items for men, women, children and the home from a bevy of designers — DKNY, Ralph Lauren, MILLY, Shoshanna, Theory, alice + olivia, Brooks Brothers, Henri Bendel, Calvin Klein, Diane von Furstenberg, Giambattista Valli, Oscar de la Renta, Stella McCartney and Temperley London.

New to the East End event, hosted by designer Donna Karan, her daughter, Gabby Karan de Felice, and talk show host and actress Kelly Ripa, will be the Lifestyle Marketplace featuring unique finds in clothing, accessories and home goods.

“We’ve asked designers and artisans to comb through their closets and archives for original pieces and unique treasures,” Karan de Felice said.

Another new addition will be Suite 1521, a members-only luxury fashion salon in Manhattan that will have a booth selling ready-to-wear items and accessories from some of its favorite brands, including ADEAM, Markus Lupfer, Giles, David Koma and Ashish.

All proceeds from the sale will go toward ovarian cancer research.

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Karan founded Super Saturday 19 years ago with her friend Liz Tilberis, who had ovarian cancer “and didn’t live to see our second Super Saturday,” said Karan, creator of the Donna Karan New York and DKNY clothing labels.

“There have been tremendous strides in research, but there still isn’t a cure,” Karan said of the disease. “While ovarian cancer is a female cancer, the whole family is affected by it — husbands, children, siblings, parents — every loved one.”

She said using fashion to raise money for ovarian cancer research and holding the sale in the Hamptons makes sense.

“Liz was the editor of Harper’s Bazaar, and I wanted to make Super Saturday a fun thing that the whole fashion industry could take part in, including their families,” Karan said. “Since everyone we knew was in the Hamptons, there was never a question of where to do it.”

Laura Finkelstein, a spokeswoman for the event, said last year’s sale raised $3.4 million.

Celebrities expected to shop include Molly Sims, Star Jones, June Ambrose, Joy Behar, Lorraine Bracco, Katherine Jenkins, Cathy Moriarty-Gentile, Aida Turturro and Jonathan Cheban.

The day’s activities will also feature a kid’s carnival and a raffle of products from Manolo Blahnik, Gucci, Coach, Barneys New York and other designers.

“It’s like a giant outdoor summer carnival, only there are designer clothes to shop, too,” Karan said. “There’s something for everyone to love.”