A Central Islip man who police said was driving drunk when he struck two cars, killing one of the drivers in November has pleaded not guilty to a 12-count indictment charging him with aggravated vehicular homicide, aggravated driving while intoxicated and other crimes, prosecutors said Tuesday.

Suffolk County District Attorney Thomas Spota's office said Louis Muicela, 39, was speeding northbound on Commack Road in Commack about 4:15 a.m. the morning after Thanksgiving when he ran a red light and struck a 2011 Lincoln Town Car heading west on Jericho Turnpike.

After striking the Lincoln, Muicela hit a 2006 Nissan that was stopped at a red light on southbound Townline Road, Suffolk police said at the time.

The Lincoln's driver, Karl Njerve, 42, of Port Jefferson Station, was pronounced dead at the scene, police said. Prosecutors said he was on his way to work as a driver for a car service.

The Nissan's driver, Carmen Lee Choy of East Northport, was not hurt.

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Tests of Muicela's blood showed he had a 0.21 percent blood-alcohol level after the crash, Spota's office said Tuesday.

State Supreme Court Justice Fernando Camacho set bail for Muicela at $250,000 cash or $500,000 bond.