Suffolk police officers and Yaphank firefighters responded late Monday night to a serious motor vehicle crash in Yaphank involving multiple victims, authorities said.

The crash occurred at about 10:46 p.m. at Yaphank Middle Island Road and Rustic Road, police said. Homicide detectives were investigating at the scene well past midnight, a police spokeswoman said.

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It was unclear early Tuesday how the crash occurred, whether more than one vehicle was involved, the number of people hurt, or the extent of their injuries.

Fire officials could not be reached for comment.