The pesticide applications are designed to control mosquitoes, which through bites can spread the West Nile virus.
Spraying of anvil in East Hampton is scheduled from 7 p.m. to 10 p.m. and will cover campgrounds, golf course and recreation areas, the department said.
Golf courses and recreation areas at Cedar Beach Town Park in Babylon will be treated with resmethrin from 7 p.m. to 10 p.m.
Chances of experiencing medical problems because of the applications are low, health officials said, but residents may want to avoid exposure, with children and pregnant women especially advised to stay indoors during the treatment and for 30 minutes after.
More information is available through the Suffolk County Division of Vector Control at 631-852-4270, the county's spraying information hotline at 631-852-4939 or by checking the "vector control" section of the health department's website at suffolkcountyny.gov/health.