Thousands of runners will hit the road Saturday and Sunday for the 43rd annual Long Island Marathon Weekend, prompting numerous temporary roadway closings and NICE bus service changes.

The main event Sunday, a 26.2-mile marathon that kicks off at 8 a.m., is estimated to draw between 6,500 and 7,500 runners, according to marathon officials. Other races Sunday include a half-marathon and a 10K race. All races that day begin on Charles Lindbergh Boulevard behind the Nassau Coliseum and finish in Eisenhower Park.

On Saturday, 1 Milers and 5K runners will start on Lindbergh Boulevard and finish inside Mitchel Athletic Complex in Uniondale.

The Long Island Marathon is a longtime tradition here on the first weekend of May, dating to the race’s first running in the 1970s. There have been some changes this year, including new start-line parking areas at Nassau Community College that should ease congestion getting into Eisenhower Park,

Some buses operated by Nassau Inter-County Express will have detours and service changes during the weekend.

The Nassau County Police Department said some of the roads may be closed earlier, or remain closed longer, than scheduled.

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For Saturday’s races, which begin at 8 a.m. and 8:30 a.m., closings include Lindbergh Boulevard, 7:30 to 10 a.m. (except Lindbergh Boulevard from Merrick Avenue to Earle Ovington Boulevard 8 to 10 a.m.), Earle Ovington Boulevard, 8 to 10 a.m., and Quentin Roosevelt Boulevard south of Commercial Avenue, 7:30 to 10 a.m.

Other closures include Meadowbrook Parkway exits and entrances to and from Lindbergh Boulevard (Nassau Coliseum, Nassau Community College) and Eisenhower Park exits, from 7:45 a.m. to 10 a.m.

Sunday’s races start at 8 a.m. and closings include Lindbergh Boulevard 5 to 10 a.m. (except Lindbergh from Merrick Avenue to Earle Ovington Boulevard, 7:15 to 10 a.m.), Merrick Avenue north of Hempstead Turnpike, 7:30 to 10 a.m., and Old Country Road from Post Avenue to School Street, 7:40 to 10 a.m.

Additional closures include School Street from Old Country Road to Railroad Avenue, 7:40 to 10 a.m., Salisbury Park Drive, 7:50 to 10:30 a.m., Railroad Avenue, 7:50 to 10 a.m., and Post Avenue from Railroad Avenue to Jericho Turnpike, 7:50 to 10:30 a.m.

There also will be closures on Jericho Turnpike from Post Avenue to Brush Hollow Road eastbound from 7:50 to 11 a.m., and Brush Hollow Road, 7:50 to 11:30 a.m. (Brush Hollow Road, south of Wantagh Parkway, will remain open.)

Also closed will be Carman Avenue from Old Country Road to Nottingham Road, 7:50 a.m. to 2 p.m., Wantagh Parkway, 7:50 a.m. to 3 p.m., and Northern State Parkway exits to Post Avenue and Wantagh Parkway.

All exits and entrances to and from Wantagh Parkway will be closed.

Runners break away from the starting line of the 1-mile race at Mitchell Athletic Complex in Uniondale on May 2, 2015. Photo Credit: Newsday / J. Conrad Williams Jr.

Meadowbrook Parkway exits and entrances to and from Charles Lindbergh Boulevard (Nassau Coliseum, Nassau Community College) and Eisenhower Park exits will be closed from 5 a.m. until 10 a.m.

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Eisenhower Park’s Park Boulevard will not allow through traffic between 7:15 and 10 a.m. The Hempstead Turnpike entrance to the park will be open throughout the day for golf and The Carltun guests, with a turnaround at the golf course until 10 a.m.

There are several service adjustments or detours on Nassau Inter-County Express:

  • Saturday: N16, 7 to 11:30 a.m. will not be making any stops on the Nassau Community College campus, and will not be making stops along Stewart Avenue between Endo Boulevard and Quentin Roosevelt Boulevard. Expect delays as a result of this detour.
  • Saturday and Sunday: N43, 7 to 11:30 a.m., will not be making stops on the NCC campus. Expect delays as a result.
  • Sunday: N22 and N24, 7 to 11:30 a.m., will not be making stops between Roosevelt Field and Hicksville, both eastbound and westbound. Buses will run express along Newbridge Road and Hempstead Turnpike instead.
  • Sunday: N35, 7 to 11:30 a.m. will not be traveling between Westbury and the Mall. All trips will begin and end at Roosevelt Field.
  • With Alfonso Castillo