Manhattan streets, particularly those around St. Patrick's Cathedral, will be closed to traffic intermittently for Pope Francis' visit from Sept. 24 to Sept. 26, according to the NYPD.

Beginning at midnight Thursday, Sept. 24, and until 9 p.m. 50th and 51st streets -- to the south and north of the cathedral -- will be closed to vehicular traffic between Madison and Fifth avenues, police said.

Other streets in the general vicinity of the cathedral, from 47th Street to 55th streets and from Madison to Sixth avenues, will be closed at other times and crosstown traffic in the area will be reduced to one lane, police said.

The FDR Drive will be closed at times Thursday, and again on Saturday, Sept. 26.

There also will be street closings on Friday around the Sept. 11 memorial downtown for the pope's visit, near Central Park for the papal motorcade, the United Nations for his address to the General Assembly, in the area of Our Lady Queen of Angels School and East 112th Street for a papal visit, and in the area of Madison Square Garden, where he will celebrate Mass.

Farther uptown, 71st and 72nd streets from Madison Avenue to Fifth Avenue, in the vicinity of the Papal Nuncio's Residence, will be closed starting Thursday until 10 a.m. Saturday. Other roadways near the residence will also be closed at times, and access for trucks and large vehicles will be curtailed, police said.

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Officials said anyone attending a papal event or entering the papal motorcade route will have to undergo security screening. Those attending cannot being aerosols, umbrellas, drones, lasers, pepper spray, selfie sticks or any other items that could be deemed a hazard.

Signs have to be cardboard, poster board or cloth and coolers with hard sides are not permitted, officials said.

Lines for security screening could be long, so those attending should allow for additional time, the officials said.

Drones and other unmanned aircraft are prohibited from operating anywhere in the five boroughs from Sept. 24 through Sept. 30, the officials said.