Two men were killed and one was wounded on the No. 2 train early Sunday after a melee that was apparently sparked by a tossed trash bag.

Officers responding to a 911 call just after 5 a.m. found two 24-year-old men with multiple stab wounds in their chests at the Houston Street station, the NYPD said. Both were taken to St. Vincent's Hospital, where they were pronounced dead.

According to published reports, one of the victims accidentally tossed a bag of trash at a man standing near the train doors, who flew into a rage. A brawl ensued, and the man is believed to have stabbed the three men with a large kitchen knife. Police arrested two men in connection to the crime, according to The Daily News, which did not provide more details.

A third victim, identified as a 23-year-old man, was in stable condition after being stabbed in the arm and neck. Subway service was disrupted for hours on No. 1, 2 and 3 lines because of the incident.

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The NYPD wouldn’t comment on the case by press time Sunday.

Bloodshed has broken out on the subways several times in recent months, with a shooting on March 7 and a stabbing last November at the D station on Seventh Avenue. Robberies are up slightly in the system, but crime was down 7 percent last month compared to February 2009, police statistics show.