Now comes the match that Serena Williams didn't want to play.

As she plows forward toward a fourth consecutive U.S. Open title and a calendar year Grand Slam, Williams runs into whom she considers the best player in the tournament in the quarterfinals tonight, the one player who might have the best shot at beating the No. 1 player in the world.

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That would be her sister, Venus, whom she has lost to 11 times.

"For me, I'm playing the best player in the tournament, and that's never easy," Serena said. "She's beaten me so many times. I've taken a lot of losses off her, more than anybody. She knows how to win, knows how to beat me, and knows my weaknesses better than anyone."