With the Mets playing shorthanded because of Curtis Granderson’s strained right calf, Juan Lagares could be activated off the disabled list as soon as Friday, general manager Sandy Alderson said.

Lagares has been rehabbing at Double-A Binghamton, where he went 1-for-4 on Thursday. The Mets hope he can avoid surgery and play through a sprained left thumb.

Granderson was out of the starting lineup on Thursday night, and Terry Collins said he was unavailable to pinch hit. But Granderson could be ready to play in two or three days, so the injury isn’t severe enough for him to be put on the 15-day DL. “It’s the worst kind of injuries,” Collins said. “For some reason, this year for us, it seems to happen once a week.”

Reyes could be close

Jose Reyes could be ready for his Flushing homecoming in three to six days, though Alderson left open the possibility of promoting the former star even sooner. “Again, we’ll just have to watch it,” Alderson said. “It would be a day-to-day proposition.” Reyes went 0-for-4 with Double-A Binghamton on Thursday night.

Wheeler’s timeline

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Zack Wheeler has resumed his rehab from Tommy John surgery, but his return date is unclear after nerve irritation prompted a delay in his comeback.

The Mets had hoped for a return shortly after the All-Star break. “I’m not relying on him as a solution to our situation over the next month, month and a half,” Alderson said. “We’ll see. Again, I wouldn’t think, based on the up-and-down way in which his rehab has gone, that we can even pencil him in for a specific date.”

Extra arm

The Mets added a fresh arm to the bullpen, promoting righthander Seth Lugo, who replaced the demoted Sean Gilmartin.

“It’s unbelievable,” said Lugo, 26, a 34th-round pick in 2011. “I’m still trying to figure out if this is real or not.”

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Lugo has a 6.55 ERA in 19 appearances, including 13 starts. But he beat the odds by reaching the big leagues for the first time.