Noah Syndergaard and Jeurys Familia are about to take a major step forward in their efforts to pitch again before the end of the season.

For the first time since suffering a lat injury in April, Syndergaard, who is with the Mets, will throw off a mound. He’s scheduled to have his first bullpen session Tuesday, Terry Collins said.

In Florida, Familia will begin a minor-league rehab assignment with the Mets’ Gulf Coast League affiliate. Familia has been sidelined since May after undergoing surgery to remove a blood clot from his right arm.

Familia is closer to a return, especially given that he won’t need as much time to ramp up for one-inning bursts out of the bullpen.

As a starter, Syndergaard will need more time once he begins his rehab assignment, though the Mets believe he still has time to return before season’s end. Pitching coach Dan Warthen mentioned the option of perhaps using Syndergaard out of the bullpen to hasten his return, but sources said the idea hasn’t gained any traction.

In another encouraging sign for the Mets, Matt Harvey will continue his rehab assignment sometime this week. He’s scheduled to throw 40 to 50 pitches in his next game. Out since mid-June with a stress injury in his shoulder, the righthander began his rehab on Saturday with an 18-pitch effort in one inning with Class A Brooklyn.

“We’ve got to figure out where we’re going to send him,” Collins said. “We haven’t decided on where his next rehab is. Hopefully, we can get the pitch count up where we’ll have a little bit better of an idea of where he is.”

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DeGrom good to go

Jacob deGrom will start Tuesday night’s Subway Series game against the Yankees. A liner struck deGrom in the right triceps in his last outing against the Phillies, but his routine between starts has not been affected.