A long night's baseball journey into morning finally ended at 2:12 a.m. Saturday, with the Yankees in a familiar spot this young season.

With another defeat.

This one was a 6-5 loss to the Red Sox in a remarkable 19 innings at the Stadium. It lasted 6 hours, 49 minutes, and the teams used 17 pitchers between them.

After the Yankees rallied to tie the score in the ninth, 16th and 18th innings, the loss went to their eighth pitcher, righthander Esmil Rogers, who pitched 21/3 innings Thursday night against the Blue Jays and was forced to go 42/3 innings against the Red Sox.

The Yankees are likely to have to make a move or two for pitching reinforcements for Saturday afternoon's game. Rogers will not be available, nor will lefty Chasen Shreve, who was brilliant in throwing 31/3 scoreless innings.

It was the longest game in Red Sox history in terms of time (6:35 was the previous high). It was the Yankees' longest home game in history and second-longest in team history (a 22-inning game that lasted 7 hours on June 24, 1962, at Detroit).

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Joe Girardi said of losing a game of that length: "It's hard. It screws you up in a lot of ways, but you have to figure out a way to come back tomorrow . . . It's one game. It seems like a lot more, but we'll move on.''

With the Yankees (1-3) an out away from defeat in the ninth inning, Chase Headley sent the game to extra innings with a solo homer to rightfield off Edward Mujica.

"It was just a wonderful game,'' Headley said. "I wish we would have won, but a great game.''

There the game stayed, at 3-3, for nearly three more hours before David Ortiz homered on an 0-and-2 slider from Rogers with one out in the 16th to put the Red Sox (3-1) ahead again.

Teixeira, batting righthanded against righthanded knuckleballer Steven Wright, tied it at 4-4 with a leadoff homer in the bottom of the 16th. Wright, who pitched five innings, wound up getting the victory.

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Teixeira's homer put a jolt into what was left of the announced crowd of 41,292 -- perhaps a couple of thousand at that point -- but the Yankees fans in the crowd soon were disappointed again when Pablo Sandoval drove in Dustin Pedroia with a one-out RBI single in the 18th that made it 5-4.

But Brian McCann led off the bottom of the inning with a double and John Ryan Murphy came in to pinch run. He went to third on Headley's groundout and Beltran -- who pinch hit in the seventh and was 0-for-5 by the 18th -- lined a double to left to tie it at 5-5.

Xander Bogaerts singled with one out in the 19th, stole second, went to third on a passed ball and scored on Mookie Betts' sacrifice fly to make it 6-5.

The Yankees had no answer this time, but they still made it somewhat interesting in the bottom half.

Jacoby Ellsbury singled but Brett Gardner -- who was caught stealing in the eighth and was picked off first in the 17th -- flied out and Garrett Jones grounded into 6-4-3 double play to end it.

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Said Headley, "Obviously, it's a tough one, but we're going to be better for it. We kept coming back. Obviously, it's tough when you play that long and come up on the short end.''

Said Brett Gardner: "I guess the good news is it's only one loss. It counts the same as a 10-0 loss . . . It feels worse than one loss, but thank goodness it's only one.''

An already long night grew longer in a strange bottom of the 12th. As lefty Tommy Layne threw a ball to Beltran to start the inning, a bank of lights went out above both foul poles, causing a 16-minute delay that prompted Red Sox manager John Farrell to pull his team off the diamond.

The Yankees later attributed the issue to a "power surge throughout the building," creating a natural segue to insert-your-own-punch-line-here attempts at humor regarding the relative lack of power otherwise on display in the ballpark, particularly from the home team.

Righthander Nathan Eovaldi, with a fastball topping out at 101 mph in the first inning of his Yankees debut, allowed three runs, eight hits and a walk in 51/3 innings. He hit a batter and threw two critical wild pitches in the sixth that contributed to two Boston runs -- on Daniel Nava's two-run single off Teixeira's glove -- that made it 3-0.

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Alex Rodriguez had an RBI single and McCann added a bases-loaded sacrifice fly in the bottom of the sixth to make it 3-2.