Wearing a black padded sleeve to protect his bruised left shoulder, Westbrook held Toronto's leading scorer, Kyle Lowry, to two points on 1-of-4 shooting. Lowry exited with 1:29 left in the second quarter with a right ankle sprain and did not return.
The Thunder led by as many as 29 points and never trailed after Durant converted a pair of free throws with 7:44 remaining in the first quarter.
Jonas Valanciunas led the Raptors with 18 points and Andrea Bargnani had 16. Toronto dropped to 1-3 and will play in Dallas on Wednesday night.
Oklahoma City coach Scott Brooks was able to rest his starters in the fourth quarter as the Thunder improved to 2-2 with their highest-scoring game of the season. Brooks played 13 of the 14 players on his roster.
The Thunder shot 50 percent from the floor in the first half to lead 57-38 at the break and finished the game shooting 47 percent. Oklahoma City will play at Chicago on Thursday.