The Colts decided not to play starting quarterback Andrew Luck against the Bills in their preseason opener, and team owner Jim Irsay suggested on Twitter that the call was made because Rex Ryan’s defense is too aggressive in these exhibition games.

“Yes,” Irsay wrote prior to kickoff of that game, “there is some truth on this dark, rainy night that my good friend Rex…has never heard of the word… PRESEASON.”

It will be interesting to see, then, how the Giants handle the Bills in Week 2 of the preseason this Saturday. They’ll be going to Orchard Park for their second game, and after holding Eli Manning out of the opener against the Dolphins, Ben McAdoo would not commit to playing his starter on Saturday.

“We’ll see,” he said on Sunday.

It was Ryan’s Jets defense that gave Manning the biggest preseason injury scare of his career when Calvin Pace popped him and opened a gash on his forehead in 2010.

The Giants have spent the preseason focusing more on their own football than that of their opponents, and McAdoo said that largely would remain the thinking this week.

“We’ll spend a little bit more time on Buffalo, but not much,” he said.

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Perhaps there should be more. The Bills are known for their outside-the-box defensive schemes and Ryan certainly could use the preseason to experiment with his looks.

“They do have some pretty interesting stuff,” Giants center Weston Richburg said. “I was watching the film from them last year and I was just looking at some of the things and I don’t even know how we identified some stuff. Hopefully we get a couple of looks [at the film]. I don’t know how crazy they will get, but I think we will be prepared.”