The Giants began 2016 with 21 players on injured reserve and are expected to add more later on Friday. Whether it’s football or blackjack, that’s a bust.

Three players — safeties Craig Dahl and Cooper Taylor and offensive tackle Marshall Newhouse — have already been ruled out for Sunday’s game with concussions and the Giants will need healthy bodies to get through the final game of the season. That could push this year’s list as high as 24.

advertisement | advertise on newsday

This will be the third straight season the Giants will be at or near the top of the NFL in players with season-ending injuries — they had 22 last year — and Tom Coughlin is perplexed by why that continues to be the case.

“We’ve changed pretty much everything in the whole program designed to become more scientific and to have more information and more knowledge and to do a better job of adjusting our practices, if that’s the way we need to do it,” Coughlin said of this year’s schedule which included recovery days on Fridays and GPS devices on players to monitor their speed and activity. “I think at the end of the year when this is all evaluated, we probably have as many injuries as we’ve ever had.”

Coughlin said he doesn’t think it is just “bad luck” that the Giants are snakebit (although no players have missed games because of an actual snake bite . . . yet).

“Do you sometimes need to have that issue (luck) that you just talked about going for you? Sure you do,” he said. “But I understand New England’s had a ton of injuries this year. Teams have to deal with this. It is no excuse, but it happens.”

advertisement | advertise on newsday

To the Giants, it seems, more than others.