CINCINNATI -- The already tenuous position of safety took a huge hit Friday night when two rookies the Giants were counting on left the game with injuries.

One of them, Mykkele Thompson, is unlikely to return this year.

Second-round pick Landon Collins injured his knee in a collision with a teammate. X-rays were negative and he returned to the sideline but not the field.

"It's not bad at all," Collins said. "It should be short-term. I did this in college one time."

Thompson hurt his Achilles while covering a Giants punt less than a minute into the second quarter and had to be carted off the field.

"It was crazy," Collins said of his fellow rookie's injury. "I just told him to keep his head up and that I would pray for him."

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Bennett Jackson replaced Collins in the secondary to play alongside starter Jeromy Miles while the first unit still was on the field.

Cornerbacks Trumaine McBride (hamstring) and Jayron Hosley (head, neck) also left the game. The Giants already are without starter Prince Amukamara (groin) and his initial replacement, Chykie Brown, who suffered a sprained LCL last week. Another starter, Dominique Rodgers-Cromartie, is fighting through a groin injury.

Tom Coughlin said McBride had been dealing with the hamstring before the game. Hosley was in a neck brace when he entered the locker room after the game. He had an MRI on his neck and was being evaluated for a possible concussion.