PHILADELPHIA -- Lawrence Tynes' career-long field goal was from 53 yards. That seems to be his limit.

The Giants' kicker missed a 54-yard game-winning attempt by about a yard with 15 seconds left in the Eagles' 19-17 win Sunday night. It came after he missed his first attempt at the long-distance field goal, but a timeout called by Eagles coach Andy Reid gave him a second chance -- which he also missed.

Two pass interference flags against the Eagles covering Ramses Barden put the Giants comfortably in field-goal range just a few moments before the ill-fated attempt, but a third pass interference call -- this one against Barden -- pushed the Giants back 10 yards . . . and one yard beyond Tynes' limit.

"We put ourselves in position a couple of times and didn't get it done," Tom Coughlin said.

The Giants fell to 2-2 and are 0-2 in the NFC East for the first time under Coughlin. The loss spoiled what would have been a thrilling comeback for the Giants, who had already erased a fourth-quarter deficit.

Eli Manning found three of his supporting cast mates to give the Giants a lead in the fourth. He hit Barden for 31 yards, Domenik Hixon for 41 and then, on second-and-goal from the 6, hit Bear Pascoe for his first career regular-season touchdown that gave the Giants a 17-16 lead with 6:45 left.

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But the Eagles drove through the Giants' defense with similar ease and took a 19-17 lead when Alex Henery kicked a 26-yard field goal, his fourth of the game. They went 75 yards on 12 plays, faced only one third down, and ate up 4:56 of play to leave the Giants with only 1:49 to try to win the game.

In the third quarter, a tackle by Mathias Kiwanuka at the 1 set up a big momentum turn for the Giants. LeSean McCoy (123 yards) had just popped a 34-yard run to get to the Giants' 23 and was on his way into the end zone on a long run with a cutback toward the middle when Kiwanuka brought him down at the 1. The Giants' defense made it stand.

After stopping McCoy twice, the Giants did it again on third-and-goal from the 1 when Antrel Rolle and Michael Boley pushed him out of bounds and the Eagles had to settle for a 10-3 lead.

Energized by the stop, and aided by a kickoff return from David Wilson (217 return yards, 36.2 average) to the 43, the Giants tied the score at 10 on an eight-play, 57-yard drive that was capped by a 14-yard pass from Manning to Victor Cruz. That tied the score at 10 with 5:28 left in the third quarter. The Eagles kicked a 48-yard field goal with 2:07 left in the quarter for a 13-10 advantage.

The Giants converted a gutsy fourth-and-1 from a shotgun formation as Manning hit Cruz for 30 yards over the middle on the last play of the third quarter, but Manning was intercepted by Dominique Rodgers-Cromartie in the end zone on the first play of the fourth. The Eagles turned that first turnover of the game into another field goal for a 16-10 lead with 9:25 remaining.

The two defenses were locked in a brutal, grinding game for most of the first half, pounding the opposing quarterbacks and forcing punts on the first nine possessions of the contest. But it was a defensive misstep that led to the first points of the game.

Osi Umenyiora, who was at his most active this season, made a spinning tackle against his nemesis McCoy on a short pass. That set up third-and-4 from the Giants' 36 and a 10th consecutive punt seemed imminent. But Umenyiora, perhaps too amped up from the play against his buddy McCoy, jumped offsides and gave the Eagles a first down.

That was the impetus the Eagles needed as they turned a potential three-and-out into an 11-play, 70-yard drive that culminated in a 19-yard touchdown pass from Vick to DeSean Jackson.

Notes & quotes: Safety Kenny Phillips left the game in the first half after his right knee buckled under him. The Giants called it a sprain and Phillips did not return.