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Indianapolis' Dwight Freeney hits Giants quarterback Eli Manning (Credit: Getty Images)

Indianapolis' Dwight Freeney hits Giants quarterback Eli Manning causing a fumble. (Sept. 19, 2010)

Week 2: Colts 38, Giants 14

In the second-ever meeting of Eli and Peyton Manning, Peyton's Colts put the hammer down on Eli's Giants, winning 38-14, sacking Eli four times and forcing him to lose two fumbles and throw one interception.

The Colts' Peyton Manning and the Giants' Eli
(Credit: AP)

The Colts' Peyton Manning and the Giants' Eli Manning head off the field after congratulating each other following a Colts' 38-14 loss. (Sept. 19, 2010)

Peyton Manning of the Colts and brother Eli
(Credit: Getty Images)

Peyton Manning of the Colts and brother Eli of the Giants exchange words after the Colts' 38-14 win in Indianapolis. (Sept. 19, 2010)

Indianapolis' Dwight Freeney hits Giants quarterback Eli Manning
(Credit: Getty Images)

Indianapolis' Dwight Freeney hits Giants quarterback Eli Manning causing a fumble. (Sept. 19, 2010)

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Giants wide receiver Mario Manningham (82) makes a
(Credit: AP)

Giants wide receiver Mario Manningham (82) makes a 54-yard touchdown reception while being defended by Colts cornerback Jacob Lacey (27) during the third quarter. (Sept. 19, 2010)

Colts tight end Dallas Clark makes a 50-yard
(Credit: AP)

Colts tight end Dallas Clark makes a 50-yard touchdown reception against the Giants during the second quarter, Sunday. (Sept. 19, 2010)

Indianapolis Colts quarterback Peyton Manning greets his brother,
(Credit: AP)

Indianapolis Colts quarterback Peyton Manning greets his brother, Giants quarterback Eli Manning, following the coin toss in Indianapolis, Sunday. (Sept. 19, 2010)

Eli Manning shows frustration while losing to the
(Credit: Getty Images)

Eli Manning shows frustration while losing to the Colts in Indianapolis, Sunday. (Sept. 19, 2010)

Giants quarterback Eli Manning, right, runs from Colts
(Credit: AP)

Giants quarterback Eli Manning, right, runs from Colts defensive end Keyunta Dawson in Indianapolis, Sunday. (Sept. 19, 2010)

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Colts defensive tackle Fili Moala reacts after a
(Credit: AP)

Colts defensive tackle Fili Moala reacts after a one-yard fumble return for a touchdown during the third quarter against the New York Giants in Indianapolis, Sunday. (Sept. 19, 2010)

The Colts defense tackles Giants tight end Travis
(Credit: AP)

The Colts defense tackles Giants tight end Travis Beckum during the second quarter in Indianapolis, Sunday. (Sept. 19, 2010)

Indianapolis Colts wide receiver Austin Collie scores a
(Credit: AP)

Indianapolis Colts wide receiver Austin Collie scores a touchdown during the second quarter after beating out Giants cornerback DJ Johnson, in Indianapolis, Sunday. (Sept. 19, 2010)

The Giants' Eli Manning waits for a play
(Credit: Getty/Andy Lyons)

The Giants' Eli Manning waits for a play from the bench during a against the Indianapolis Colts. (Sept. 19, 2010)

A Colts fan holds up a sign during
(Credit: Getty Images)

A Colts fan holds up a sign during a game against the New York Giants. (Sept. 19, 2010)

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The Colts' Joseph Addai runs with the ball
(Credit: Getty Images)

The Colts' Joseph Addai runs with the ball during his team's game against the Giants. (Sept. 19, 2010)

Colts running back Donald Brown jumps into the
(Credit: AP)

Colts running back Donald Brown jumps into the arms of teammate Jamey Richard as Pierre Garcon joins the celebration after Brown scored a touchdown against the Giants in the first quarter. (Sept. 19, 2010)

Giants running back Ahmad Bradshaw, center, is stopped
(Credit: AP)

Giants running back Ahmad Bradshaw, center, is stopped by Colts defenders Fili Moala, left, and Philip Wheeler in the first quarter. (Sept. 19, 2010)

Giants quarterback Eli Manning throws a pass against
(Credit: Getty Images)

Giants quarterback Eli Manning throws a pass against the Indianapolis Colts at Lucas Oil Stadium. (Sept. 19, 2010)

Colts wide receiver Austin Collie, left, flips over
(Credit: AP)

Colts wide receiver Austin Collie, left, flips over Giants cornerback Corey Webster in the first quarter in Indianapolis. (Sept. 19, 2010)

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The Colts' Peyton Manning gives instructions to his
(Credit: Getty Images)

The Colts' Peyton Manning gives instructions to his team during their game against the Giants at Lucas Oil Stadium in Indianapolis. (Sept. 19, 2010)

Colts quarterback Peyton Manning, left, and his brother,
(Credit: AP)

Colts quarterback Peyton Manning, left, and his brother, Giants quarterback Eli Manning, talk during warmups before the start of their game. (Sept. 19, 2010)

Colts quarterback Peyton Manning, left, and his brother,
(Credit: AP)

Colts quarterback Peyton Manning, left, and his brother, Giants quarterback Eli Manning shake hands during warmups before a game in Indianapolis. (Sept. 19, 2010)

Giants quarterback Eli Manning, left, and Colts quarterback
(Credit: AP)

Giants quarterback Eli Manning, left, and Colts quarterback Peyton Manning talk before their game in Indianapolis. (Sept. 19, 2010)

Eli Manning of the Giants talks with head
(Credit: Getty Images)

Eli Manning of the Giants talks with head coach Tom Coughlin before their game in Indianapolis. (Sept. 19, 2010)

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