FALCONS (1-0) AT GIANTS (0-1), Sunday, 1 p.m.

TV: Ch. 5; Radio: WFAN (660, 101.9)

Giants by 21/2; O/U: 51

Hey Eli, Mann to Mann, what's up with telling Rashad Jennings not to score? Don't you know he's on my fantasy team?! I still won my matchup, which can't be said for Manning and the Giants. Their mismanagement of the clock allowed the Cowboys to steal a win from them. There's no such thing as a must-win in Week 2, but the Giants need some positive vibes. It won't be easy against the Falcons, who showed in a Monday night win that they're a new team under coach Dan Quinn. Save for a couple drives, the defense held the Eagles in check. The Giants' offense didn't look good in Dallas, and had the ball for only 22:50. I can see Atlanta also dominating time of possession. Oh, and who exactly is going to stop Julio Jones?

The pick: Falcons

MONDAY NIGHT LOCK OF THE WEEK

JETS (1-0) AT COLTS (0-1), 8:30 p.m.

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TV: ESPN, Ch. 11; Radio: ESPN (98.7)

Colts by 7; O/U: 461/2

You can't overreact after one week, but Indy's defense isn't stopping anyone. Andrew Luck and the offense looked bad, too, and could be without No. 1 WR T.Y. Hilton. The Jets, meanwhile, crushed the Browns. It's a familiar scenario: Home team, off a bad loss, vs. underdog, off a big win. Lay the points and cover easily, right? Not so fast. Indy outscored opponents 458-369 last season, but take away four wins over Jaguars and Titans (combined 135-47 score) and it's only plus-1. The Colts gave up 147 rushing yards to Buffalo last week, and Chris Ivory, one of the hardest runners in the league, will run wild. Look, Luck's numbers (18-7-1 ATS at home vs. 15-14 ATS on road) say Indy bounces back. But I say the Jets, flying under the radar, make a statement. Broadway Joe guaranteed a Super Bowl III win over Colts. Newsday Joe calls another upset: Jets 24, Colts 20.

The pick: Jets

SUNDAY'S 1 P.M. GAMES

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PATRIOTS (1-0) AT BILLS (1-0)

Patriots by 1; O/U: 45

The AFC East was 4-0 in Week 1. This one has so many story lines I don't know where to start. Edge goes to Tom Brady (23-3 straight up vs. Bills) and Bill Belichick with 10 days to plan.

The pick: Patriots

TEXANS (0-1) AT PANTHERS (1-0)

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Panthers by 3; O/U: 391/2

The Texans went from "Hard Knocks" to "Curb Your Enthusiasm" in one week. Already, they've made a QB change as Bill O'Brien dropped the hammer on Brian Hoyer in favor of Ryan Mallett. Carolina has Cam Newton, who is 4-1 career vs. AFC South.

The pick: Panthers

RAMS (1-0) AT REDSKINS (0-1)

Rams by 31/2; O/U: 41

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A letdown could be in play here for Rams, but I just don't see it.

The pick: Rams

TITANS (1-0) AT BROWNS (0-1)

Titans by 1; O/U: 41 1/2

Whether it's Johnny Manziel or Josh McCown at QB for Browns, Marcus Mariota and Titans will win. Why? Because of Dick LeBeau, the legendary 'D' coordinator now calling plays for Titans. His teams are 27-3 against rookie QBs since 1995, and Manziel (6 games, 0-2 as starter) is essentially a rookie.

The pick: Titans

CARDINALS (1-0) AT BEARS (0-1)

Cardinals by 2; O/U: 451/2

Bears are 4-15 ATS in last 19 at home. To quote former Cardinals coach Dennis Green, "The Bears are who we thought they were!"

The pick: Cardinals

CHARGERS (1-0) AT BENGALS (1-0)

Bengals by 3; O/U: 461/2

San Diego is 10-0 ATS in last 10 September games. I'll take it.

The pick: Chargers

BUCS (0-1) AT SAINTS (0-1)

Saints by 10; O/U: 47

No. 1 overall pick Jameis Winston's first pass was a pick-6. I think he will be a bust. Can you say JaMarcus Winston? Drew Brees should light up Bucs at the Superdome.

The pick: Saints

49ERS (1-0) AT STEELERS (0-1)

Steelers by 6; O/U: 451/2

In case you didn't stay up late Monday night: The 49ers looked golden. Carlos Hyde was the bruising back he was at Ohio State, and the new Jim in town, coach Tomsula, had his team ready for prime time. The 1 p.m. start for a West Coast team scares me a bit, but I think 49ers keep it close.

The pick: 49ers

LIONS (0-1) AT VIKINGS (0-1)

Vikings by 21/2; O/U: 43

Adrian Peterson gets 25 touches after 10 in Week 1. Lions are 2-12 ATS in last 14 as road underdog.

The pick: Vikings

SUNDAY'S 4 P.M. GAMES OR LATER

COWBOYS (1-0) AT EAGLES (0-1), 4:25 p.m.

TV: Ch. 5; Radio: WFAN (660, 101.9, joined in progress)

Eagles by 5; O/U: 55

Starting 2-0 with wins over the Giants and Eagles would put the Cowboys in the driver's seat in the NFC East. Tony Romo won't have Dez Bryant (broken foot) or DeMarco Murray (now with Eagles). Murray will want to show his old team what they're missing, but Chip Kelly's new offense is too much of a work in progress to lay five points. Three reasons to back Dallas: 1) They went 8-0 straight up on the road last season. 2) They're 8-1 ATS in last nine road games. 3) The underdog in Dallas games is an astounding 58-25 ATS since 2010.

The pick: Cowboys

DOLPHINS (1-0) AT JAGUARS (0-1), 4:05 p.m.

Dolphins by 6; O/U: 411/2

TV: Ch. 2

The Dolphins didn't look good in a Week 1 win, but now get the Jags, who have not covered a spread in September since 2012, a stretch of 10 games. Miami in a rout.

The pick: Dolphins

RAVENS (0-1) AT RAIDERS (0-1), 4:05 p.m.

Ravens by 6 1/2; O/U: 43

Joe Flacco threw for 117 yards and two INTs (one a pick-6) last week. Perfect remedy: Facing Oakland, which is 7-15 ATS in last 22 home games. Instead of flying home after Denver loss, Ravens stayed out west. Smart move that pays off.

The pick: Ravens

SUNDAY NIGHT

SEAHAWKS (0-1) AT PACKERS (1-0), 8:30 p.m.

TV: Ch. 4 Radio: WFAN (660, 101.9)

Packers by 31/2; O/U: 49

Marshawn Lynch and his mom are big talkers. Who knew? Before she took to social media to call for the Seahawks' offensive coordinator's job, Lynch himself did more talking in an episode of "The League" last week than at the Super Bowl. That wouldn't have happened if Packers didn't fall apart in the NFC title game. Think Aaron Rodgers & Co. circled this one on the calendar? The leader of the Pack is 45-10 straight up all-time at home with 122 TDs and 22 INTs. I hope Mama Lynch doesn't read this, because she won't like it: The Seahawks are not a playoff team this year.

The pick: Packers

STAFF PICKS (best bets in caps)

JOE MANNIELLO (Last week: 7-8-1, 1-0 best bets): Falcons JETS Patriots Panthers Rams Titans Cardinals Chargers Saints 49ers Vikings Cowboys Dolphins Ravens Packers

BOB GLAUBER (Last week: 8-7-1, 1-0): GIANTS Colts Patriots Panthers Rams Browns Bears Bengals Saints Steelers Vikings Eagles Dolphins Raiders Packers

TOM ROCK (Last week: 9-6-1, 1-0): Giants Jets PATRIOTS Pathers Rams Titans Cardinals  Chargers Saints Steelers Lions Eagles Dolphins Ravens Packers

KIMBERLEY A. MARTIN (Last week: 8-7-1, 1-0): Giants Colts Patriots Texans Rams Browns Cardinals Chargers Bucs 49ers Lions Cowboys Dolphins RAVENS Packers