GIANTS (4-3) AT SAINTS (3-4), 1 p.m.

TV: Ch. 5; Radio: WFAN (660, 101.9)

Saints by 3; O/U: 48 1/2

Earlier this season, the Giants could've marched into New Orleans and walked out with a Big, Easy win. Now, Drew Brees' shoulder appears to have healed and the team has won three of four. The Saints have lost six of their last eight at the Superdome, and if there's anyone who can feel right at home there it's New Orleans native Eli Manning. His top target, Odell Beckham Jr., who is from Baton Rouge, Louisiana, and played at LSU, is getting healthier. I expect the duo to put up some points. Even though the Giants needed a pick-6 and 100-yard kickoff return to win last week, I still think they're the better all-around team in this matchup. Take the points.

The pick: Giants

JETS (4-2) AT RAIDERS (3-3), 4:25 p.m.

TV: Ch. 2, Radio: ESPN (98.7)

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Jets by 3; O/U: 45

This game could have AFC wild-card playoff implications, and should be close, so don't expect CBS to pull an NBC and switch off for "Heidi." The Jets missed a golden opportunity at New England last week, but I don't think that carries over. A win here puts the Jets in good position to contend for a playoff spot. Go look at their schedule and tell me they can't win 10 games. The Raiders have matched their win total from last season, and Derek Carr-to-Amari Cooper has them on the rise. But I think they'll struggle vs. the Jets' different looks and Darrelle Revis. The Jets have a 41-3 advantage in third quarters this season. Their 'D' delivers the win.

The pick: Jets

1 P.M. GAMES

BUCS (2-4) AT FALCONS (6-1)

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Falcons by 7; O/U: 49 1/2

Atlanta easily could be on a three-game losing streak. Tampa Bay is playing better on offense and led 24-0 last week before a meltdown in Washington. The Bucs lost, 56-14, at Atlanta on a Thursday night last year, and I see Lovie Smith using that as motivation.

The pick: Bucs

TITANS (1-5) AT TEXANS (2-5)

Texans by 3 1/2; O/U: OFF

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It's been nothing but hard knocks for Houston. Last week it trailed 41-0 at halftime, and then lost Arian Foster for the season. The Titans have lost five straight, the last four at home. Three of those losses were by 1, 2 and 3 points. Maybe a road trip will help.

The pick: Titans

LOCK OF THE WEEK: BENGALS (6-0) AT STEELERS (4-3)

Steelers by 1 1/2; O/U: 48

Mention Andy Dalton's name and the first thing you'll hear is, "He can't win in the first round of the playoffs." Well, guess what: If he continues to play the way he has this season, the Bengals will have a bye in the first round. So there! Cincy is 5-0-1 against the spread (ATS). Ben Roethlisberger (16-6 vs. Bengals) returns, but he won't be at 100 percent. Dalton is 2-6 vs. Pittsburgh, but he's having a career year (14 TDs, 2 INTs, 1,761 yards, 116.1 QB rating). The Bengals are off a bye, and I think this is a statement game for Dalton and the Bengals.

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The pick: Bengals

CHARGERS (2-5) AT RAVENS (1-6)

Ravens by 3 1/2; O/U: 50 1/2

The Ravens' six losses are by a combined 30 points. The Chargers are 0-3 on the road. Joe Flacco (45-13 straight up in Baltimore) bests Philip Rivers in a shootout.

The pick: Ravens

CARDINALS (5-2) AT BROWNS (2-5)

Cardinals by 6; O/U: 46 1/2

Cleveland has played well at home, but I can't see it stopping Arizona's offense.

The pick: Cardinals

49ERS (2-5) AT RAMS (3-3)

Rams by 8; O/U: 39

San Fran will come to play after its no-show on national TV. Still, Todd Gurley and Rams should put up enough points to cover the spread.

The pick: Rams

VIKINGS (4-2) AT BEARS (2-4)

Bears by 1 1/2; O/U: 42

This line has moved significantly after Vikings opened as two-point favorites. There's a reason for that. After an 0-3 start, Bears have won two of three. Chicago was on a bye last week, and teams' records the week after a bye this season are 7-3 straight up and 9-1 against the spread. You say good bye, I say hello.

The pick: Bears

LIONS (1-6) VS. CHIEFS (2-5)

TV: Ch. 5, 9:30 a.m., in London

Chiefs by 4; O/U: 46

This London game is on TV, plus we get an extra hour of sleep, so set your alarm. (Oh, wait, they're a combined 3-11? Set it for noon). Lions won a thriller in London last year. This should be a close game.

The pick: Lions

4 P.M. GAME

SEAHAWKS (3-4) AT COWBOYS (2-4)

TV: Ch. 5

Seahawks by 6; O/U: 41

America's Team Turmoil is 0-4 without Tony Romo. Adding insult to injury, Greg Hardy last week auditioned for a role in "Bad Boys 3." (Apparently, this is happening. Google it). Instead of pushing his special teams coach, he could turn his attention to Russell Wilson, who has been sacked a league-high 31 times. Dallas' pass rush plus the possible return of Dez Bryant equal a cover.

The pick: Cowboys

SUNDAY NIGHT

PACKERS (6-0) AT BRONCOS (6-0), 8:20 p.m.

TV: Ch. 4 Radio: WFAN (660, 101.9)

Packers by 2 1/2; O/U: 45 1/2

This is the best matchup of the season, but not because it's Aaron Rodgers vs. Peyton Manning. It's Rodgers (15 TDs, 2 INTs) vs. the Broncos defense (17 points per game). Green Bay's 'D' is allowing a league-low 16.8. Both teams are off a bye, so I expect a close game. The edge goes to Rodgers over Manning, who despite all his pizza commercials, hasn't delivered (7 TDs, 10 INTs).

The pick: Packers

MONDAY NIGHT

COLTS (3-4) AT PANTHERS (6-0), 8:30 p.m.

TV: ESPN Radio: WFAN (660, 101.9)

Panthers by 7; O/U: 46 1/2

Indy is a mess, but this is the NFL, and when you think there's no way a team can be competitive, it usually is. Carolina may be looking ahead to next week, when it hosts the Packers in what could be 7-0 vs. 7-0. Underdogs on Monday night are 6-2, so I'll take a shot.

The pick: Colts

STAFF PICKS (best bet in ALL CAPS)

JOE MANNIELLO (51-51-3, 4-2-1 best bets; Last week: 7-7): Giants Jets Bucs Titans BENGALS Ravens Cardinals Rams Bears Lions Cowboys Packers Colts

BOB GLAUBER (54-48-3, 4-3; Last week: 7-7): Saints Raiders Falcons Texans Steelers Ravens Browns Rams Vikings Chiefs SEAHAWKS Packers Panthers

TOM ROCK (51-51-3, 5-1-1; Last week: 9-5): Giants JETS Falcons Titans Steelers Ravens Cardinals Rams Vikings Chiefs Cowboys Packers Panthers

KIMBERLEY A. MARTIN (51-51-3, 2-5; Last week: 7-7): Giants Jets Falcons Texans Steelers Ravens Cardinals Rams VIKINGS Lions Seahawks Packers Panthers