JETS (4-1) AT PATRIOTS (5-0), 1 p.m.

TV: Ch. 2; Radio: ESPN (98.7)

Patriots by 8 1/2; O/U: 47 1/2

Jets-Pats may not have all the hype of recent seasons -- you can thank the mild-mannered Todd Bowles for that -- but it's one of the week's best matchups. First place on the line. Pats' NFL-best offense (36.6 points per game) vs. Jets' league-best defense (15 ppg). Tom Brady vs. Darrelle Revis. Brady is 20-6 straight up against Jets. Ryan Fitzpatrick gets his first taste of rivalry, but the QB has struggled in his career vs. Pats: 1-6 record with 17 INTs. If he continues to have success throwing to Brandon Marshall (four straight games with at least seven catches and 100 yards), this will be a close game. Chris Ivory will be able to run against Pats' 'D' allowing 114.6 rushing yards per game. Pats win, but Jets keep it inside number.

The pick: Jets

COWBOYS (2-3) AT GIANTS (3-3), 4:25 p.m.

TV: Ch. 5; Radio: WFAN (660, 101.9)

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Giants by 4; O/U: 45

The NFC East is a game of Hot Potato: "You take it . . . No, you take it!" The Giants had a chance to grab control with a win in Philly but fell apart. Is there any team that needs a win more than the Cowboys? They're 0-3 without Tony Romo, and now turn to Matt Cassel after ending the Brandon Weeden Experiment. Cassel hasn't started since Week 3 of last season. But he's had success (34 career wins), and Dallas smartly chose to watch a new episode of Cassel than another Weeden rerun. Everyone will say this is a revenge game, a chance at redemption for Giants after their Week 1 meltdown. True, but it's also a rivalry game. Dallas has won nine of its last 10 on road, and I see this being a slugfest won by a field goal.

The pick: Cowboys

BILLS (3-3) VS. JAGUARS (1-5) At London, 9:30 a.m.

Bills by 4; O/U: 41

If you thought this matchup was unwatchable, wait until next week when the Lions and Chiefs (combined 2-10) play in London. Jags have not fared well in London (outscored 73-27 in two games). A London mauling is just what Rex Ryan and struggling Buffalo needs.

The pick: Bills

1 P.M. GAMES

TEXANS (2-4) AT DOLPHINS (2-3)

Dolphins by 5; O/U: 44 1/2

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Miami responded to interim coach Dan Campbell, scoring nearly as many points last week (38) as it did during three-game losing streak (48). The defense got six sacks after having one in first four games. Miami hasn't played in home stadium since Week 3, a 41-14 loss to the Bills. Don't think that isn't a motivating factor.

The pick: Dolphins

LOCK OF THE WEEK

BROWNS (2-4) AT RAMS (2-3)

Rams by 6; O/U: 41 1/2

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The Browns have led the league in dramatic finishes. After losing on a last-second field goal in Week 4, they followed that up with back-to-back overtime games. Rams, off a bye, will have the fresher legs. Speaking of fresh legs, have you seen Todd Gurley run? The rookie missed the first two games, hardly played in Week 3 and then racked up 305 yards on 49 carries the next two games. Guess which team is the worst at stopping the run in the NFL? Yep, the Browns, who have allowed a whopping 149.8 yards per game.

The pick: Rams

STEELERS (4-2) AT CHIEFS (1-5)

Line OFF (Steelers QB)

Landry Jones faces a tough environment in his first NFL start, but the former Oklahoma quarterback is used to intense Midwest crowds. Sooner or later, Chiefs have to stop losing streak, but that secondary won't be able to stop Antonio Brown and Martavis Bryant.

The pick: Steelers

SAINTS (2-4) AT COLTS (3-3)

TV: Ch. 5

Colts by 4; O/U: 52

As long as the Colts don't try any fake punts, they'll be fine. Indy is 1-2 at home, 0-2 with Andrew Luck. That changes against a Saints defense that is allowing an NFL-worst 409.7 yards per game.

The pick: Colts

FALCONS (5-1) AT TITANS (1-4)

Falcons by 5; O/U: 47

Atlanta bounces back from its first loss against a Titans team that likely won't have Marcus Mariota and is 1-10 in last 11 home games.

The pick: Falcons

VIKINGS (3-2) AT LIONS (1-5)

Vikings by 2 1/2; O/U: 44

Detroit's second win will have to wait, as Adrian Peterson (192 total yards in Week 2 win over Lions) and Vikings defense (allowing second-fewest points per game at 16.6) have big days.

The pick: Vikings

BUCS (2-3) AT REDSKINS (2-4)

Redskins by 3; O/U: 42 1/2

Redskins have played well at home and Bucs have played well on road, so take the team getting points and coming off a bye.

The pick: Bucs

4 P.M. GAME

RAIDERS (2-3) AT CHARGERS (2-4)

Chargers by 4; O/U: 47

Finally, I didn't incorrectly pick a Raiders game . . . because they were on a bye last week. The six teams that have had their bye this season are 5-1 overall and 6-0 ATS the next week. San Diego continues to find new ways to lose close games, and I think this is a toss-up field-goal game. Give me the points as I look to snap personal 0-5 ATS Oakland streak. The pick: Raiders

SUNDAY NIGHT

EAGLES (3-3) AT PANTHERS (5-0), 8:20 p.m.

TV: Ch. 4

Radio: WFAN (660, 101.9)

Panthers by 3; O/U: 46

The Eagles have won two straight and three of four, but Sam Bradford continues to throw interceptions. Three more last week gave him nine on the season. Carolina's defense is tied for third with eight INTs and should feast on Bradford. Panthers could experience letdown after thrilling comeback win in Seattle, but playing in prime time prevents that.

The pick: Panthers

MONDAY NIGHT

RAVENS (1-5) AT CARDINALS (4-2), 8:30 p.m.

TV: ESPN

Radio: WFAN (660, 101.9)

Cardinals by 9; O/U: 48

So if the 49ers beat the Ravens by five, and the Cardinals beat the 49ers by 40, Arizona should beat Baltimore by 45, right? If only picking NFL games were that easy. Here's simpler math: Cards' 203 points are an NFL-best while Ravens' 162 allowed are fifth-most. Add that to Carson Palmer's 12-3 straight-up home record with Arizona and it equals a cover.

The pick: Cardinals

STAFF PICKS

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JOE MANNIELLO 44-44-3, 3-2-1 best bets

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BOB GLAUBER 47-41-3, 3-3

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