Rafael dos Anjos will make his first UFC lightweight title defense on Saturday, Dec. 19, when he fights Donald “Cowboy” Cerrone in Orlando, Florida.

The UFC on Fox 17 main card airs live on Fox beginning at 8 p.m. ET from the Amway Center.

Here is the full fight card heading into Friday’s weigh-ins.

Main card, 8 p.m. ET on Fox

Rafael dos Anjos (champion) vs. Donald Cerrone — Lightweight championship

Junior Dos Santos vs. Alistair Overeem

Nate Diaz vs. Michael Johnson

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Karolina Kowalkiewicz vs. Randa Markos

Prelims on Fox Sports 1, 5 p.m.

Myles Jury vs. Charles Oliveira

C.B. Dollaway vs. Nate Marquardt

Sarah Kaufman vs. Valentina Shevchenko

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Tamdan McCrory vs. Josh Samman

Danny Castillo vs. Nik Lentz

Jim Alers vs. Cole Miller

Prelims on Fight Pass, 3:30 p.m. ET

Leon Edwards vs. Kamaru Usman

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Hayder Hassan vs. Vicente Luque

Luis Henrique vs. Francis Ngannou