Andy Roddick, the 2003 Open champion and former No. 1, was sluggish and defensive -- perhaps the lingering aftermath of a mild case of mononucleosis that struck him earlier this summer -- falling to Janko Tipsarevic 3-6, 7-5, 6-3, 7-6 (4) in Arthur Ashe Stadium.

In a day of upsets, 18-year-old American Ryan Harrison upset 15th-seeded Ivan Ljubicicof Croatia 6-3, 6-7 (4), 6-4 for his first Grand Slam match victory, and Wimbledon runner-up Tomas Berdych also lost in the first round, beaten 7-6 (3), 6-4, 6-4 by 35th-ranked Michael Llodra of France.

Lleyton Hewitt and Marcos Baghdatis are other surprising early-round victims.

After last night's showing it is clear Tipsarevic is under-ranked. He's no slouch. He missed three weeks before the tournament with an injured ankle, stroked 66 winners -- 26 more than Roddick -- and won 81 percent of his first-serve points with zero double faults.

Contrasting the almost laconic Tipsarevic, Roddick looked lost at times and lacked energy. On the broadcast, the McEnroes were begging Roddick to blast a scorching serve to get the crowd into it and energize him.

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Roddick was serving at 2-5 in the third set with the match square, when he was called for a foot fault. Replays showed the call was an accurate one, but Roddick nearly lost his mind. He was still fuming when Tipsarevic took the set.

"I have to change my shorts," Roddick said as he stalked past chair umpire Enrick Molina. "That's ridiculous."

Now the question has to be asked, is it time to for a new American to sweep us off our feet?

On the day that Harrison won his first match -- and was joined by emerging players Sam Querrey and John Isner in the second round -- Roddick looked old and tired.