A year ago Tim Smyczek, then 26 years old and ranked 109th, was the last American man to be eliminated from the U.S. Open. In the third round.

Smyczek, who has spent most of his career in the tennis minor leagues, is up to 90th in the rankings and on Tuesday won his first-round match over Filip Krajinovic, a qualifier from Serbia, in four sets. For now, though, Smyczek has Yank company.

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John Isner, at No. 13 the only seeded U.S. male in the tournament, knocked off 21-year-old wild card Marcos Giron, this year's NCAA champion from UCLA, in straight sets. Sam Querrey, once ranked as high as 17th but now 57th, needed five sets to defeat 82nd-ranked Maximo Gonzalez of Argentina.

But 21-year-old Jack Sock, often cited as a part of a new wave of American players, is out of the tournament after retiring with a strained calf while trailing Spain's Pablo Andujar, 6-4, 3-6, 6-1.

In other significant results, five-time champion Roger Federer defeated Australia's 76th-ranked Marinko Matosevic, 6-3, 6-4, 7-6 (4), and No. 4 seed David Ferrer of Spain knocked off 119th-ranked Damir Dzumhur of Bosnia-Herzegovina, 6-1, 6-2, 2-6, 6-2.