Roger Federer marches on in the U.S. Open. That's after he marched John Isner, the last American man, out of the tournament Monday night.

Isner lost his big serve only once, but that was the last one and it was game, set and match for Federer. He won 7-6 (0), 7-6 (6), 7-5. With Donald Young going out early in the day, the quarterfinals won't include an American.

"Obviously, he is one of the best servers in the game," Federer said. "The pace on his second serve is unreal. I just had to make sure to hang around and make sure I held my serve."

Isner had won 110 consecutive service games at the Open spanning the past two years before he was broken by Federer.

Isner couldn't break Federer once, and unless he won points on his serve or at the net, Isner couldn't win any of the rallies.

Federer will play Richard Gasquet in the quarterfinals. Gasquet defeated Tomas Berdych, 2-6, 6-3, 6-4, 6-1.

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After there were no breaks of serve in the first set, the serve made all the difference in the tiebreak. Isner couldn't hold his and Federer dominated with his. By the time Federer won the first two points on Isner's serve, he was on a 3-0 run that couldn't be stopped. He served two aces and then Isner couldn't handle either of Federer's returns on the next points, and the tiebreak was over in an instant.

Isner had not lost 7-0 in 428 previous official tour-level tiebreaks.

Federer again couldn't break Isner in the second set. Isner served first and the game went to seven deuces, with Isner saving two break points. Federer saved four break points on his service in the next game but held. After Isner went out to a 5-3 lead in the tiebreak, Federer won the next three points but missed a backhand that would have won it. Then his return winner and a backhand passing shot gave him the second set.

Federer couldn't break Isner in the third set, when he held three break points in the eighth game. Federer made three errors, including an easy backhand that could have given him the game. Federer was two points from the match on Isner's serve in the 10th game, but Isner's big serves got him out of trouble.

Then he was broken a single time, and he was out of the tournament.