U.S. Open wild card Tim Smyczek, a 25-year-old journeyman from Wisconsin, after his five-set, four-hour victory that put him in a Grand Slam third round for the first time, was asked about running out of gas.

Not being tired. Literally running out of gas. It was before his first-round match, being driven to the National Tennis Center, that his courtesy car's fuel tank hit "E" in Queens. Smyczek guessed that his driver somehow "thought she was going to be able" to coast the last five or six miles.

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He was picked up on the roadside by a stranger, won that match, and on Friday defeated Alex Bogomolov Jr. of Russia, 3-6, 7-6 (6), 2-6, 6-4, 6-4. And, yes, he was feeling weary.

"I'll go see the trainers, get a massage, probably get some takeout," he said. "If I'm able to stay awake until the takeout gets to my room, I'll eat some."

Late Friday night, 2001 U.S. Open champ Lleyton Hewitt, now 32, eliminated No. 6 seed Juan Martin del Potro, 6-4, 5-7, 3-6, 7-6 (2), 6-1. Del Potro was the 2009 champ.

Earlier, Open co-favorites Novak Djokovic and Andy Murray cruised, and three Americans lost.

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Qualifier Donald Young, a 24-year-old with up-and-down results, was beaten by German Florian Mayer, 7-5, 6-3, 6-4. Denis Kudla, the Open's 2010 junior champion, lost to fifth seed Tomas Berdych of the Czech Republic, 7-6 (3), 7-6 (3), 6-3. Rajeev Ram, ranked 128th, lost to Spaniard Marcel Granollers, 3-6, 4-6, 6-2, 6-3, 7-5.