She has teamed with syndication veterans Dick Robertson and Scott Carlin for another syndicated talk show, the Reporter said on its Web site, noting that the show is being eyed for fall 2011 launch - coinciding with the exit of "The Oprah Winfrey Show."
The news was first reported on Showbiz411.com.
O'Donnell, who turns 48 today, has worked with Robertson and Carlin before.
Robertson, as president of Warner Bros. Domestic TV Distribution, shepherded the sales of the Telepictures-produced "Rosie O'Donnell Show," according to the Reporter.
Carlin, who most recently served as head of HBO Domestic Distribution until he left last June, was part of Robertson's team at Warner Bros. and also was involved in the sales of the "The Rosie O'Donnell Show," the Reporter said.
The O'Donnell show ran for six years, ending in 2002, and won multiple Emmy Awards.
O'Donnell also was a host on ABC's "The View" in 2006 and '07.