"The Help" also claimed the guild's ensemble award, the show's equivalent of a best-picture prize, The Associated Press reports.
Jean Dujardin won the lead-actor honor for "The Artist" as a silent-film superstar whose career crumbles when the sound era arrives. Christopher Plummer won for supporting actor as an elderly dad who comes out as gay in "Beginners."
The wins boost the actors' prospects for the same honors at the Feb. 26 Academy Awards.
"You can't name me, without naming those other wonderful women on 'Hot in Cleveland,' " the 90-year-old White said. "This nomination belongs to four of us. Please, please know that I'm dealing them right in with this. I'm not going to let them keep this, but I'll let them see it."