The cast of "Inglourious Basterds" won the Screen Actors Guild trophy for best film ensemble Saturday, the last award of the night.
It also took home the evening's first film acting trophy. Christoph Waltz won for best supporting actor.
The SAG Awards are all about the stars of TV and film honoring their own, The Associated Press reports.
Jeff Bridges won best actor for his portrayal of a hard-living country music singer in "Crazy Heart," and Sandra Bullock won best actress for "The Blind Side," as the tenacious shepherd to a youngster in need who becomes a football star.
The cast of AMC's 1960s Madison Avenue saga "Mad Men" won the trophy for best drama series ensemble for the second year in a row, while 19 cast members of Fox TV newcomer "Glee," about misfits in a high school singing club, accepted the award for best comedy series ensemble.
Mo'Nique's searing portrayal of an abusive mother in "Precious" was honored as best supporting actress in a film.
Fey was instantly shocked at the trophy's heft. "SAG is the heaviest of any award," she said. "It weighs 100 pounds!"
She added that she was completely surprised by her win. "I really, really expected to lose," she confessed.