For 25 years, Oprah Winfrey reigned as the queen of talk shows. Take a look at some of her show's biggest moments.
Television talk-show host Oprah Winfrey shows off her new figure during taping of her show after she lost 67 pounds following a liquid diet and exercise.
John F. Kennedy Jr., Sept. 3, 1996
John F. Kennedy Jr. talks to Oprah Winfrey during a taping of "The Oprah Winfrey Show" on Tuesday, Aug. 27, 1996. On the show, which aired nationally on Tuesday, Sept. 3, 1996, Kennedy spoke about George Magazine, the auction of his mother's possessions, and childhood memories.
Tony Bennett, April 7, 1997
Oprah Winfrey is surprised by Tony Bennett, who unveiled a portrait he painted of her, during a taping of "The Oprah Winfrey Show" on March 26, 1997. The show aired nationally on Monday, April 7, 1997.
Garth Brooks, Feb. 6 1998
Oprah Winfrey breaks into a smile as Garth Brooks plays guitar during the taping of the "The Oprah Winfrey Show" in Amarillo, Texas, on Friday, Feb. 6, 1998.
Robert Duvall and John Travolta, Nov. 30, 1998
Actor Robert Duvall, left, dances a tango with host Oprah Winfrey while actor John Travolta watches during taping of "The Oprah WInfrey Show" on Tuesday, Nov. 24, 1998. The show aired on Monday Nov. 30.
Sidney Poitier, April 7, 2000
Talk-show host Oprah Winfrey is embraced by actor Sidney Poitier during taping of "The Oprah Winfrey Show" on March 30, 2000. Winfrey's one-hour interview with the legendary actor, whom she says she has dreamed of her whole career, aired nationally on Friday, April 7.
Al Gore, Sept. 11, 2000
Democratic presidential candidate Vice President Al Gore gives talk show host Oprah Winfrey a high five during the taping of "The Oprah Winfrey Show" on Sept. 11, 2000.
George W. Bush, Sept. 19, 2000
In response to Oprah Winfrey's question, "What's your favorite dream?" Republican presidential candidate Texas Gov. George W. Bush responds by making a gesture symbolizing being sworn in as the next president of the United States during taping of "The Oprah Winfrey Show" on Tuesday, Sept. 19, 2000.
Nelson Mandela, Nov. 27, 2000
Former South African President Nelson Mandela joins talk-show host Oprah Winfrey on Nov. 17, 2000, for the taping of "The Oprah Winfrey Show" at Harpo Studios in Chicago. The show aired nationally on Nov. 27.
Michael J. Fox, April 3, 2002
Actor Michael J. Fox demonstrates to Oprah Winfrey the loss of control of his body, explaining that it is often the result of medication rather than the symptoms of Parkinson's disease, during a taping of "The Oprah Winfrey Show" on Monday, April 1, 2002. The show aired nationally April 3.
Bono, Sept. 17, 2002
Oprah Winfrey wears the glasses of Irish rock star Bono during a taping of "The Oprah Winfrey Show" on Sept. 17, 2002. The two talked about their mutual concerns about issues confronting Africa.
Coretta Scott King, May 5, 2003
Coretta Scott King shows off her new look during the taping of "The Oprah Winfrey Show" in Chicago on April 23, 2003. About the makeover Winfrey said, "Even living legends need to spice it up every decade or so." King said she liked the new look. "I feel great," she said. King was one of several celebrities and audience members who received the "age-defying makeovers." The show aired nationally May 5.
Arnold Schwarzenegger and Maria Shriver, Sept. 15, 2003
California gubernatorial candidate Arnold Schwarzenegger and his wife, Maria Shriver, appear with Oprah Winfrey on Sept. 15, 2003, on the set of "The Oprah Winfrey Show." It is the couple's first interview together since he announced his bid for governor in his state's recall election.
Oprah Winfrey gives audience members a free car, Sept. 9, 2004
Talk show host Oprah Winfrey sits atop a Pontiac G6 outside her Chicago studio, on Sept. 9, 2004, surrounded by some of the 276 people from her audience who each received one of the new cars at the start of the show to celebrate the premiere of her 19th season.
Tom Cruise, May 23, 2005
Tom Cruise appears on "The Oprah Winfrey Show" on May 23, 2005.
James Frey, Jan. 26, 2006
Oprah Winfrey during her live television interview with James Frey, author of "A Million Little Pieces," on Jan. 26, 2006. Winfrey challenged Frey over his disputed memoir during the telecast, asking him to explain why he "felt the need to lie." Frey's story of substance abuse and recovery became one of the best-selling books of 2005 after Winfrey named it to her book club last fall, with countless addicts citing it as inspiration.
Nate Berkus, Dr. Mehmet Oz and Dr. Phil McGraw
Oprah Winfrey is seen with interior designer Nate Berkus, Dr. Mehmet Oz and Dr. Phil McGraw, during "The Oprah Winfrey Show" live from Radio City Music Hall in New York. The show is ending its run on May 25, 2011, after 25 years, and millions of her fans around the globe are waiting to see how she will close out a show that spawned a media empire. The three are Winfrey's proteges, who she fostered to their own television stardom.
Oprah Winfrey tells the audience they're going to Australia, Sept. 9, 2010
Oprah Winfrey stands with audience members on Sept. 9, 2010, after making the announcement she will be taking the studio audience on a trip to Australia during taping of "The Oprah Winfrey Show" in Chicago. The premiere of the 25th and final season aired Monday, Sept. 13, 2010.
The Jacksons, Nov. 8, 2010
Talk-show host Oprah Winfrey is seen with the Jacksons, during an interview with Katherine Jackson, second from left, mother of the late pop star Michael Jackson, in a taping of "The Oprah Winfrey Show" in Encino, Calf., on Oct. 9, 2010. Looking on are Joe Jackson, Michael's father, and Michael's three children from left, Prince, Paris and Blanket. The show aired nationally Monday, Nov. 8, 2010.
Patricia, Jan. 24, 2011
Talk-show host Oprah Winfrey greets her half-sister Patricia on an episode of "The Oprah Winfrey Show" taped at Harpo Studios, on Jan. 19, 2011. On the show that aired Monday, Jan. 24, 2011, a sometimes-emotional Winfrey introduced Patricia, by explaining how the woman's years-long search for her family culminated in a meeting with Winfrey on Thanksgiving Day of last year.
Barack and Michelle Obama, April 27, 2011
President Barack Obama and first lady Michelle Obama are pictured with host Oprah Winfrey during a taping of "The Oprah Winfrey Show" at Harpo Studios in Chicago, on April 27, 2011.