A disabled Glen Cove man who has been missing for two weeks kept to a routine of getting coffee, picking up medicine and visiting friends around town and rarely, if ever, left the area, his family and police said Monday.

Nunzio Izzo, 56, who takes medication for epilepsy and a heart condition, was last seen Dec. 17, a Monday, leaving the Glen Cove home of a friend in a taxi, police said. A Silver Alert has been issued, and both Glen Cove and Nassau police are searching for him.

Police said they have no indication he is dead and will consider him a missing person until they find evidence of foul play.

"He'll maybe spend a couple days with his girlfriend, but he has never been gone for two weeks," said Izzo's brother-in-law, Anthony Bocchino, 56, of Glen Cove. Izzo's family is worried that he may not have his pills with him.

"I suspect the worst," Izzo's brother, Lorenzo, 53, of Glen Cove, said. "I've been very hopeful and very positive, but I suspect the worst because this is not his usual way."

Nunzio Izzo's six nieces and nephews, who range in age from 16 to 29, have been frantically searching for him, posting messages on Facebook, making and hanging posters around the city and driving and asking around for any sign of their uncle, Lorenzo Izzo said.

The Izzo family typically spends Christmas Eve together. But this holiday was the first without Nunzio at the table.

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"It was mostly for the kids," Lorenzo Izzo said of their bittersweet holiday outing this season. "They love him and he loves them."

Nunzio Izzo cannot drive and relies on taxis, friends and buses to get around, his family said. His usual schedule includes going to Dunkin' Donuts, picking up prescriptions at CVS and hanging out at Italian social clubs, they said. Though he is limited physically and relies on a pacemaker for his heart, Izzo has no mental disabilities, Bocchino said.

Izzo, who lives with his elderly mother in Glen Cove, is well-known and liked as a regular customer by local cabdrivers, Bocchino said. The family has not been able to reach Izzo by phone and his voice mail box is full, Bocchino said.

Police on Monday said they were exploring all leads and had interviewed everyone who may have come in contact with Izzo, including those with the taxi company that picked him up the night of Dec. 17.

"It's a baffling case. He just kind of up and disappeared," Glen Cove Det. Lt. John Nagle said. He could not say where the cab took Izzo and could not comment on Izzo's cellphone records or where the signal was last traced.

Bocchino said the taxi may have taken Izzo home, but "who knows after that."

"It's a gray area," he said of the cab's destination.

Anyone with information about Izzo should call Glen Cove police at 516-676-1002.