The expressway was closed between exits 40, Jericho Turnpike and 41, Routes 106 and 107, for about four hours following the 8:15 p.m. accident, police said.
The woman first hit a tractor-trailer on the entry ramp of Exit 40, Jericho Turnpike, police said.
She then hit a box truck on the expressway, police said.
The woman was taken to a nearby hospital with minor injuries, police said. The other drivers were not hurt, police said.
No other details were available.
On the westbound side, a disabled car caused traffic delays, police said.
According to the state transportation website, westbound lanes were closed just west of Exit 40W.