But for millions of movie fans, he will always be grumpy Uncle Vernon, the least magical of characters in the fantastical "Harry Potter" movies.
Griffiths died Thursday at University Hospital in Coventry, central England, from complications following heart surgery, his agent said. He was 65.
Griffiths won a Tony Award for "The History Boys" and appeared in dozens of movies and TV shows. But he will be most widely remembered as a pair of contrasting uncles -- Harry Potter's Uncle Vernon Dursley and Uncle Monty in the cult film "Withnail and I."
Griffiths was among a huge roster of British acting talent to appear in the "Harry Potter" series of films released between 2001 and 2011. His role, as the grudging, magic-fearing guardian of orphaned wizard Harry, was small but pivotal.
Griffiths once said he liked playing Uncle Vernon "because that gives me a license to be horrible to kids." But Radcliffe recalled Griffiths' kindness to the young star.
"Richard was by my side during two of the most important moments of my career," said Radcliffe, who in 2007 starred with Griffiths in a London and Broadway production of "Equus." "In August 2000, before official production had even begun on 'Potter,' we filmed a shot outside the Dursleys', which was my first ever shot as Harry. I was nervous, and he made me feel at ease.
"Seven years later, we embarked on 'Equus' together. It was my first time doing a play, but, terrified as I was, his encouragement, tutelage and humor made it a joy."
Earlier, Griffiths was the louche, lecherous Uncle Monty to Richard E. Grant's character Withnail in "Withnail and I," a low-budget British comedy about two out-of-work actors that has become a cult classic.
A huge stage presence with a grace rendered all the more striking by his physical bulk, Griffiths created roles including the charismatic teacher Hector at the emotional heart of Alan Bennett's school drama "The History Boys." He won an Olivier Award for the part in London and a Tony for the Broadway run, and repeated his performance in the 2006 film adaptation.
National Theatre artistic director Nicholas Hytner, who directed "The History Boys," called Griffiths' performance in that play "a masterpiece of wit, delicacy, mischief and desolation, often simultaneously."
Griffiths was born in northeast England's Thornaby-on-Tees in 1947 to parents who were deaf and mute -- an experience he and his directors felt contributed to his exceptional ability to listen and to communicate physically.
Griffiths left school at 15 but later studied drama and spent a decade with the Royal Shakespeare Company, making a specialty of comic parts such as the buffoonish knight Falstaff.
He had parts in movies ranging from historical dramas "Chariots of Fire" and "Gandhi" to slapstick farce "The Naked Gun 2 1/2."
Griffiths' last major stage role was in a West End production of Neil Simon's comedy "The Sunshine Boys" last year opposite Danny DeVito. The pair had been due to reprise their roles in Los Angeles later this year.