A 1996 Oldsmobile Cutlass was driving east in the westbound lanes when it hit a Suzuki Grand Vitara around 6:50 p.m., police said.
The driver of the Oldsmobile, who was alone in the car, was killed, according to police.
The westbound lanes of Sunrise Highway at Exit 63 were reopened around 11 p.m. Eastbound lanes remained open for travel.
Police did not immediately know whether alcohol was a factor in the crash.