A Port Jefferson woman is dead and her husband is seriously injured after a Saturday afternoon crash involving two vehicles that temporarily closed a section of Route 25A in Rocky Point, officials said.

Florin Tilinca was driving a Jeep east on Route 25A preparing to stop at the traffic light at Fairway Drive about 12:20 p.m. when a Subaru traveling west crossed the median and struck Tilinca’s Jeep, Suffolk County police said in a news release. Port Jefferson resident Lucio Costanzo, 73, was driving the Subaru with his wife, Stephanie Costanzo, 73, as a passenger. Lucio Costanzo was airlifted to Stony Brook University Hospital and is in serious condition, police said. Stephanie Costanzo was taken to John T. Mather Hospital where she was pronounced dead, police said.

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Officers closed Route 25A in both directions from Fairway Drive to Westchester Drive until shortly before 4 p.m.

The main thoroughfare is flanked on either side by shopping centers that house a Planet Fitness and Kohl’s, among other businesses.

Tilinca and her 16-year-old son were taken to St. Charles Hospital and treated for non-life-threatening injuries, police said.