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Study: IVF unrelated to test-tube babies' cancer rate

CHICAGO - For the first time, a large study suggests a higher rate of childhood cancer among test-tube babies, but researchers say the reason probably has nothing to do with how the infants were conceived.

More likely, it's related to the genetics of the parents who turned to in vitro fertilization because of infertility, the study's Swedish authors and other experts say. Also, test-tube infants often are born prematurely and have breathing problems at birth, traits linked in other studies with increased cancer risks.

Still, cancer in these children is rare, despite any elevated risks.

"It's rather reassuring," said Dr. Bengt Kallen, the study's lead author and a researcher at the University of Lund. The risk "is so small that it can't matter much for the individual parents or parents-to-be."

The study examined Swedish children conceived by IVF, in which eggs are fertilized with sperm in a lab dish, then implanted in the womb. Research on possible health risks including cancer and birth defects in IVF children has had mixed results.

Dr. Tommaso Falcone, the Cleveland Clinic's obstetrics and gynecology chief, said it's uncertain whether similar results would be found in the more racially diverse United States.

The results of the new study were published online today in Pediatrics.

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