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Study suggests drug is safe for morning sickness

For the first time, a large study shows that pregnant women who suffer morning sickness are not risking harm to their babies if they take a certain anti-nausea drug.

The result may lead more doctors to prescribe the drug metoclopramide and women to feel less guilty aboutusing it during their baby's crucial first few months of development, experts said.

Currently, no drugs are approved in the U.S. for morning sickness, which plagues most women in the first threemonths of pregnancy -- even all day for some. Doctors sometimes use medicines approved for other types ofnausea that are thought to be safe in pregnancy, when simple strategies such as eating crackers and frequent,small meals don't help.

The study looked back at nearly 82,000 births in Israel, where metoclopramide is commonly used. It found nodifference in birth defects or other problems in newborns of women whether or not they took the drug, sold asReglan and in generic form.

"I think that women will be comforted by this," said Dr. Keith Eddleman, director of obstetrics at Mount SinaiMedical Center in New York. "Most women are reluctant (to take anti-nausea medicine) just because of thestories they've heard and the perception that taking something in the first trimester can cause harm." Results ofthe study, which did not look at the drug's effectiveness, were reported in Thursday's New England Journal ofMedicine.

Morning sickness can be more than unpleasant. It can cause some women to lose weight or send them to thehospital. But some doctors and women are reluctant to use medicine because of scares decades ago over a coupledrugs used for morning sickness.

Thalidomide, used in Europe and Canada in the 1960s, caused missing or shortened limbs. The maker of anotherdrug, Bendectin, pulled it from the market in 1983 after widely publicized lawsuits alleged it caused limbdeformities. Multiple studies and reviews by medical authorities never found such a link.

Despite the millions of births each year -- about 4 million in the U.S. alone -- there still have been no large,well-designed studies on the safety of medicines in treating morning sickness, mainly due to fears of harming afetus and triggering lawsuits.

The Israeli study, led by researchers at Ben-Gurion University, included pregnant women enrolled in Israel'slargest HMO from 1998 through 2007.

It compared the health of newborns of 3,458 women who took metoclopramide, for as little as a week to morethan three weeks, with 78,245 newborns of women who had not used it. Rates of problems were low and similar inboth groups.

The safety finding may reassure women, who often are more cautious than their doctors about using a drugduring pregnancy, said Dr. Laura Riley, a Massachusetts General Hospital obstetrician and spokeswoman for theSociety for Maternal Fetal Medicine.

"For some who are on the fence, it'll allow them to take it," she said.

In the U.S., other drugs -- Compazine, Phenergan and Zofran -- are generally used more often than Reglan,which is made by Schwarz Pharma Inc. of Smyrna, Ga. The new study should lead obstetricians to prescribe itmore often, some experts said.

Until now, doctors have only assumed it is safe, based on a couple small studies and the lack of reports of seriousproblems, said Dr. Jeffrey Chapa, head of maternal fetal medicine at the Cleveland Clinic.

Metoclopramide, which works by speeding emptying of the stomach and reducing heartburn, can have sideeffects, including sedation, insomnia, depression and anxiety.


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