Edwin Encarnacion and Eric Thames added solo shots as the Blue Jays won back-to-back games for the first time since Aug. 31-Sept. 1 in Baltimore.
Toronto opened the scoring with four in the second against Andrew Miller (6-3), highlighted by Arencibia's home run, a drive into the third deck in left, his 22nd and second in as many days.
Encarnacion hit a one-out shot to right off Miller in the third, his 16th. Miller allowed five runs and eight hits in five innings to lose his second straight start.
The Red Sox lost for the fourth time in five games and failed to gain ground on the first-place Yankees, who lost, 5-4, in 10 innings to Baltimore earlier in the day. The Red Sox are 2 1/2 games behind the Yankees with 19 left to play.
Konerko's 10th career grand slam tied Robin Ventura's White Sox record and capped a seven-run seventh.
Hamels (14-7) gave up solo home runs to Yuniesky Betancourt and Corey Hart, but kept Milwaukee from mounting any big innings in a game between the two best teams in the National League. The lefthander pitched his third complete game of the year, walking two and striking out two.
The visiting Dodgers said before the game Andre Ethier's season is over. In a year in which he put together a 30-game hitting streak, the 29-year-old outfielder has been shut down for the season with a right knee injury. -- AP