Host Syracuse waited too long to turn up the intensity against Louisville, and the second-ranked Orange paid for the lapse Sunday.
Samardo Samuels scored all eight of his points during a late surge and Jerry Smith sank a pair of clutch free throws with 17.8 seconds left as Louisville rallied past Syracuse, 66-60.
The Cardinals (16-9, 7-5 Big East), who trailed by 11 in the first half, hung on to win despite missing 5 of 7 free throws in the final 1:41, including a pair by Smith just two seconds after the two he converted.
It was the fifth straight win over the Orange for Louisville, which was 0-4 against ranked teams entering the game.
Syracuse (24-2, 11-2), which held off Connecticut, 72-67, on Wednesday night after squandering a 16-point lead in the second half, had won 11 straight.
Orange leading scorer Wes Johnson, with a bruised thumb on his right (shooting) hand, was 5-for-20 from the floor and had a pair of shots blocked in the final minute.
Samuels' dunk off an inbounds pass gave the Cardinals their biggest lead at 59-52 with 3:04 to go.
Six straight free throws by the Orange closed the gap to 62-58 with 64 seconds remaining, but Syracuse was unable to score again after Kris Joseph's slam dunk with 31.9 seconds left made it a two-point game.
Rutgers 71, Georgetown 68: Jonathan Mitchell scored a career-high 24 points, three more than he had against the No. 7 Hoyas in a 25-point loss last month, and the host Scarlet Knights beat a top 10 team for the first time in seven years.
Mitchell shot 9-for-12, making his first seven shots, including four three-pointers, and Rutgers (13-12, 3-9) kept Georgetown (18-6, 8-5) from going on any extended runs.
Greg Monroe had 19 points, eight rebounds, six assists and four rebounds and Austin Freeman had 17 points for the Hoyas, who were coming off a 103-90 victory over No. 4 Villanova and next face No. 2 Syracuse on Thursday.
Seton Hall 79, DePaul 71: Jeremy Hazell scored 18 points, Jeff Robinson 16 and Seton Hall held off a late DePaul rally in Newark. It was the Blue Demons' 20th straight road loss. Herb Pope had 15 rebounds for the Pirates (14-9, 5-7 Big East), whose 17-point lead early in the second half dwindled to four points twice in the final minute. Will Walker had 19 points to lead DePaul (8-16, 1-11), and freshman Tony Freeland scored a career-high 18 points.- AP