The top-seeded Orange not only lost, 91-84, to No. 8 Georgetown in Thursday's Big East quarterfinal, but big man Arinze Onuaku suffered an apparent knee injury with 5:07 left in the second half.
The 6-9, 269-pound F/C went up to block a Georgetown lay-up and immediately grabbed his right knee when he landed. He writhed in pain underneath on the Hoyas baseline and had to be helped off the court and into the locker room.
Syracuse -- which was a shoo-in to receive a No. 1 seed in the NCAA tournament along with Duke, Kansas and Kentucky -- also was a favorite to win the national title.
But if Onuaku's injury is serious (which it appeared to be at the time), that will change.
Georgetown's Chris Wright led all scorers with 28 points. Austin Freeman added 18 and Jason Clark had 17 for the Hoyas (22-9). Big East PoY Wes Johnson had 24 point for Syracuse (28-4). Teammates Scoop Jardine and Kris Joseph chipped in 19 and 18 points, respectively.